Partner Università degli Studi di Milano-Bicocca

Coordination, leader of WP4: IN2SIGHT operation validation in vivo

Giuseppe Chirico

Coordinator.
Role in the project: Coordination of the project; development of the scanning system and adaptive optics protocols; imaging of labeled cells in the In2Sight; fluidodynamic studies in the nude chip implanted in the micro-fluidic device.

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Maddalena Collini

Role in the project: design of in vitro/ and in vivo optical testing of the chip and of In2Sight; image correlation measurements of hemodynamics in the chip.

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Francesca Granucci

Role in the project: coordination of the implant protocols for the IN2SIGHT chip and mice breed bearing multiple fluorescent immune cells.

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Laura Sironi

Role in the project: design of in vitro/ and in vivo optical testing of the chip and of In2Sight; image correlation measurements of hemodynamics in the chip.

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Laura D'Alfonso

Role in the project: design of in vitro/ and in vivo optical testing of the chip and of In2Sight; image correlation measurements of hemodynamics in the chip.

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Margaux Bouzin

Role in the project: image correlation spectroscopy of cell cultures on the in2sight chip.

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Mario Marini

Role in the project: implementation and test of in2sight optical setup. Postdoc position on the project.

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Main Task

Project coordination
Development of protocols for the x-y optical raster scanning of the chip
Test of the non-linear imaging capabilities
Selection of transgenic mice
Analysis of the immune dynamics induced by biomaterial
Tissue histopathology
Comparison of the immunoreaction
Dynamics with numerical simulations

Partner Description

The Università di Milano-Bicocca, UNIMIB founded in 1998, is one of the most dynamic, research- and innovation-oriented Italian universities and includes 14 Departments with about 33,000 students enrolled (2017/18 year).

UNIMIB has 117 patents and 13 spin-offs, exploiting opportunities from a broad range of technological commercial sectors: nanomedicine and biotechnology, therapeutic and diagnostic, energy and environment, smart materials and ICT.

The Physics Department of UNIMIB enrolls about 40 staff scientists and has basic research programs in all major fields of Physics: Particle Physics, Theoretical Physics, Astrophysics, Biophysics, Plasma Physics and Electronics.

The Department of Biotechnology and Biosciences BTBS at the University of Milano-Bicocca has been founded in 1999 as a multidisciplinary institute. It is composed of 30 independent research groups working on Organic, Biomolecular and Computational Chemistry, Biochemistry, Molecular Biology, Physiology, Genetics, Pharmacology, Microbiology, Fermentation Chemistry, Immunology, Biophysics, Zoology, Botany and Ecology.